If you watched any of David Sinclair videos you probably noticed that he looks younger than he actually is. When I saw the video it made me think that this guy must be doing something that works for him. I did some research, and that brought me to his Joe Rogan podcast, where he explains exactly what he is doing to stay young. 

I would highly suggest that you go watch the video as he gives out a massive amount of valuable information. 

David Sincalir on Joe Rogan about Anti Aging

I will first give you an overview of all the things he does and then later try to explain how everything comes together

List of things David Sincalir consumes or does

  1. NMN 1g in the morning
  2. Resveratrol 0.5g in the morning
  3. Metformin 1g in the evening
  4. Intermittent fasting
  5. Exercise 
  6. Hot Sauna immediately followed by cold water

Key Takeaways:

Sirtuins are genes which protect all organisms from deterioration and disease. NMN and Resveratrol are molecules which essentially mimic the effects of the sirtuin genes.

NMN also boosts NAD levels (which sirtuins need to function)

NMN supplement

Nicotinamide mononucleotide is a nucleotide derived from ribose and nicotinamide. Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide.

Formula: C11H15N2O8P
Molar mass: 334.2192 g/mol


Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts.

Molar mass: 228.25 g/mol
Formula: C14H12O3
Solubility in water: 0.03 g/L
Melting point: 261 to 263 °C (502 to 505 °F; 534 to 536 K)
Appearance: white powder with; slight yellow cast
Solubility in DMSO: 16 g/L


Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain. It is taken by mouth.

Molar mass: 129.1636 g/mol
Formula: C4H11N5
Excretion: Urine (90%)
Trade name: Glucophage, other
Bioavailability: 50–60%
Elimination half-life: 4–8.7 hours

How does Metformin work?

There are 3 pathways related to aging:

  • AMP-activated protein kinase (AMPK) – Metformin targets this pathway
  • Sirtuin pathways – NMN and Resveratrol help with this one
  • mTOR – this is a pathway in the body activated by protein/amino acids. The only way to effect this pathway without fasting or eating a lower protein diet, is through a drug called Rapamycin. David doesn’t take or recommend it – he says it’s too risky to do just yet

Intermittent fasting

Intermittent fasting is an umbrella term for various eating diet plans that cycle between a period of fasting and non-fasting over a defined period. Intermittent fasting is under preliminary research to assess if it can produce weight loss comparable to long-term calorie restriction.

The main idea is that you ideally skip a meal or two, therefore putting your body in a state of starvation which triggers different processes in the body, which are proved to have a broad variety of benefits, some of them include anti ageing benefits.

Regular exercise 

David recommends performing exercise regularly. He recommends running and doing resistance training. 

Hot Sauna immediately followed by cold water

David especially recommends exposing your body to temperature extremes which force your body to kick start protective mechanisms. He recommends doing a hot sauna immediately followed by cold water submersion.


I am happy father of two and a health and fitness enthusiast.

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